Expression of the Nd1 gene is down-regulated by doxorubicin at post-transcriptional level

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Expression of the Nd1 gene is down-regulated by doxorubicin at post-transcriptional level.

Doxorubicin is an anti-neoplastic agent with cardiotoxicity as a side effect. We previously demonstrated that doxorubicin treatment of mice resulted in a selective decrease in expression of the Nd1 gene, which encoded a new kelch family actin binding protein in the heart. Here we show that doxorubicin treatment also reduced the Nd1 expression in various organs of mice and cultured cell lines. T...

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ژورنال

عنوان ژورنال: International Journal of Molecular Medicine

سال: 2006

ISSN: 1107-3756,1791-244X

DOI: 10.3892/ijmm.18.5.963